5-Chloro-2-thiophenecarboxylic acid → {5-[(5-Chloro-thiophene-2-carbonyl)-amino]-tetrazol-2-yl}-acetic acid methyl ester

HRID 901050Notes

Reaction equation

HRID 901050 reaction equation
[CH3:1][O:2][C:3](=[O:11])[CH2:4][N:5]1[N:9]=[N:8][C:7]([NH2:10])=[N:6]1.[Cl:12][C:13]1[S:17][C:16]([C:18](O)=[O:19])=[CH:15][CH:14]=1>>[CH3:1][O:2][C:3](=[O:11])[CH2:4][N:5]1[N:9]=[N:8][C:7]([NH:10][C:18]([C:16]2[S:17][C:13]([Cl:12])=[CH:14][CH:15]=2)=[O:19])=[N:6]1

Participants

3

Reactant 2

HCID 950485-Chloro-2-thiophenecarboxylic acidHCID 42643124methyl 2-(5-amino-2H-1,2,3,4-tetrazol-2-yl)acetate

Product 1

HCID 42643127{5-[(5-Chloro-thiophene-2-carbonyl)-amino]-tetrazol-2-yl}-acetic acid methyl ester

Procedure

63.2 Using general method D, (5-amino-tetrazol-2-yl)-acetic acid methyl ester was coupled with 5-chlorothiophene-2-carboxylic acid to give {5-[(5-chloro-thiophene-2-carbonyl)-amino]-tetrazol-2-yl}-acetic acid methyl ester. White solid. MS 302.0 ([M+H]+)

Sources & evidence

ORD record
ord-03f8dfc177d34cd9bd0b59857852425b
Source dataset
uspto-grants-2008_04
Patent number
US07361672B2

Reaction notes

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