Bromomethylcyclopropane → HCID 69280336, compound

HRID 901093Notes

Reaction equation

[N:1]1([C:7]([C:9]2[NH:10][C:11]3[C:16]([CH:17]=2)=[CH:15][C:14]([O:18][C@H:19]2[CH2:23][CH2:22][NH:21][CH2:20]2)=[CH:13][CH:12]=3)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH2:25][CH:26]1[CH2:28][CH2:27]1>>[CH:26]1([CH2:25][N:21]2[CH2:22][CH2:23][C@H:19]([O:18][C:14]3[CH:15]=[C:16]4[C:11](=[CH:12][CH:13]=3)[NH:10][C:9]([C:7]([N:1]3[CH2:2][CH2:3][O:4][CH2:5][CH2:6]3)=[O:8])=[CH:17]4)[CH2:20]2)[CH2:28][CH2:27]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 69282983HCID 69282983, compound

Product 1

HCID 69280336HCID 69280336, compound

Procedure

According to the procedure described for the synthesis of [5-((S)-1-Isopropyl-pyrrolidin-3-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone the title compound was synthesized from Morpholin-4-yl-[5-((S)-pyrrolidin-3-yloxy)-1H-indol-2-yl]-methanone and bromomethyl-cyclopropane. The title compound was obtained as light yellow solid. MS (m/e): 370.3 (MH+, 100%).

Sources & evidence

ORD record: ord-33b05b20d0b145918b6427acbec31251
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07361682B2

Reaction notes

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