反应详情

A solution of 20.2 g (0.067 mol) 6-benzyloxy-5-fluoro-1H-indole-2-carboxylic acid methyl ester in 800 ml ethyl acetate was treated with 2 g (10%) Pd/C and hydrogenated at 1 bar for 2 h. After filtration and evaporation the residue was re-crystallized from ethyl acetate. The crystals were filtered off washed with diethyl ether and dried at 40° C. under vacuum to yield 10.9 g (74%) of the title compound as white crystals. MS (m/e): 208.1 (MH−, 100%).

1. filtrationAfter filtration and evaporation the residue
2. customwas re-crystallized from ethyl acetate
3. filtrationThe crystals were filtered off
4. washwashed with diethyl ether
5. customdried at 40° C. under vacuum