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A solution of 4-Imidazoleacetic acid, sodium salt, hydrate (compound ix, where R2 is H) (3.0 g, 18.1 mmol) in MeOH (50 ml) was cooled to about 0° C. and anhydrous HCl gas was bubbled into the mixture for about 15 minutes while maintaining reaction temperature below about 5° C. The reaction was stirred for about 12 hour at room temperature and then solvents were removed under reduced pressure to yield an oil which solidifies on standing. Mass spec 141.0 MH+, NMR (300 MHZ, DMSO-d6, 30° C.), 9.0-9.2 (1H, s), 7.47.6 (1H, s), 3.85-3.95 (2H, 3), 3.6-3.7 (3H, s).

1. customanhydrous HCl gas was bubbled into the mixture for about 15 minutes
2. temperaturewhile maintaining
3. customreaction temperature below about 5° C
4. customsolvents were removed under reduced pressure
5. customto yield an oil which