5-Nitro-2-phenyl-2H-pyrazolo [3,4-b]pyridine → 2-Phenyl-2H-pyrazolo[3,4-b]pyridin-5-amine

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Reaction Steps

A suspension of 3B (350 mg, 1.458 mmol) and palladium (5% wt) on activated carbon (300 mg) in EtOAc(100 mL) and MeOH (200 mL) was stirred under a hydrogen balloon for 1 hour. The reaction mixture was filtered via a pad of Celite. The filtrate was concentrated under reduced pressure to give the title compound as a light brown solid (305 mg, 99% yield). LC/MS (method A): retention time=1.60 min, (M+H)+=211.

Provenance & Evidence