Naphthalene → 2-Naphthol

HRID 901817Notes

Reaction equation

HRID 901817 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.C1([OH:21])C2C(=CC=CC=2)C=CC=1>>[CH:9]1[C:10]2[C:5](=[CH:4][CH:3]=[CH:2][CH:1]=2)[CH:6]=[CH:7][C:8]=1[OH:21]

Participants

3

Reactant 2

HCID 931NaphthaleneHCID 70051-Naphthol

Product 1

HCID 86632-Naphthol

Procedure

A further selective hydroxylation reaction was carried out with the sol-gel-embedded CYP BM-3 on the substrate naphthalene. 77% of the precursor were hydroxylated. The main product obtained was 1-naphthol (85%), and 2-naphthol was obtained as by-product (15%) (detected by gas chromatography).

Workup

  1. customA further selective hydroxylation reaction
  2. customThe main product obtained

Sources & evidence

ORD record
ord-ce55d738f0c848d28cf32b3480e4ec81
Source dataset
uspto-grants-2008_04
Patent number
US07364884B2

Reaction notes

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