Hydrochloric Acid → HCID 23134841, compound

HRID 901822Notes

Reaction equation

HRID 901822 reaction equation
C([O:3][C:4](=[O:28])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]2[CH:24]=[C:23]([F:25])[C:22]([F:26])=[C:21]([F:27])[CH:20]=2)=[CH:7][CH:6]=1)C.[OH-].[Na+].Cl>O1CCOCC1>[F:25][C:23]1[CH:24]=[C:19]([CH:20]=[C:21]([F:27])[C:22]=1[F:26])[O:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([C:4]([OH:28])=[O:3])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68538336HCID 68538336, compound

Product 1

HCID 23134841HCID 23134841, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2.75 g of 4-[6-(3,4,5-Trifluoro-phenoxy)-hexyloxy]-benzoic acid ethyl ester was dissolved in 100 ml of 1,4-dioxane, and then 100 ml of a 1.0M NaOH solution was added thereto. After stirring for one day, the reaction solution was acidified with a 10% HCl solution and filtered to obtain a solid. The solid was recrystallized from ethanol to afford 4-[6-(3,4,5-trifluoro-phenoxy)-hexyloxy]-benzoic acid (yield: 62%).

Workup

  1. filtrationfiltered
  2. customto obtain a solid
  3. customThe solid was recrystallized from ethanol

Sources & evidence

ORD record
ord-0527506a7af0491fb7549268e55b3eba
Source dataset
uspto-grants-2008_04
Patent number
US07364940B2

Reaction notes

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