1,3-Dibromopropane → HCID 59700564, compound

HRID 901837Notes

Reaction equation

HRID 901837 reaction equation
[CH3:1][CH:2]1[O:7][C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[NH:4][CH2:3]1.[Br:12][CH2:13][CH2:14][CH2:15]Br>>[CH3:1][CH:2]1[O:7][C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[N:4]([CH2:15][CH2:14][CH2:13][Br:12])[CH2:3]1

Participants

3

Reactant 2

HCID 80011,3-DibromopropaneHCID 103969772-Methyl-3,4-dihydro-2H-1,4-benzoxazine

Product 1

HCID 59700564HCID 59700564, compoundYield 48%

Procedure

From 2-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine (4.5 g, 1 eq, 30.2 mmol) obtained in step (iii) above, and 1,3-dibromo propane (30 ml, 10 eq, 300 mmol) and following the procedure of step (iv), preparation 17 title compound (3.5 g, yield 48%) was obtained as viscous oil.

Sources & evidence

ORD record
ord-6b3daebceb9648569edc5d25976e297f
Source dataset
uspto-grants-2008_04
Patent number
US07365064B2

Reaction notes

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