1,3-Dibromopropane → HCID 59700579, compound

HRID 901839Notes

Reaction equation

HRID 901839 reaction equation
[CH2:1]([CH:4]1[O:9][C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[NH:6][CH2:5]1)[CH2:2][CH3:3].[Br:14][CH2:15][CH2:16][CH2:17]Br>>[CH2:1]([CH:4]1[O:9][C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[N:6]([CH2:17][CH2:16][CH2:15][Br:14])[CH2:5]1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 80011,3-DibromopropaneHCID 10012469HCID 10012469, compound

Product 1

HCID 59700579HCID 59700579, compoundYield 33%

Procedure

From 2-propyl-3,4-dihydro-2H-benzo[b][1,4]oxazine (1.65 g, 1 eq, 9.3 mmol) obtained in step (iii) above, and 1,3-dibromo propane (9.4 ml, 10 eq, 93 mmol) and following the procedure of step (iv), preparation 17 title compound (915 mg, yield 33%) was obtained as viscous oil.

Sources & evidence

ORD record
ord-c7c2249214ad4b4fa5ce2dac2d307dfe
Source dataset
uspto-grants-2008_04
Patent number
US07365064B2

Reaction notes

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