HCID 10180845, compound → HCID 178467707, compound

HRID 901845Notes

Reaction equation

HRID 901845 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7](=[O:27])[CH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([O:24][CH2:25][CH3:26])[C:21]([OH:23])=[O:22])=[CH:15][CH:14]=2)[C:3]2[CH:28]=[CH:29][CH:30]=[CH:31][C:2]1=2.[NH2:32][C@H:33]([C:41]([OH:43])=[O:42])[CH2:34][CH2:35][CH2:36][NH:37][C:38](=[NH:40])[NH2:39]>CO>[NH2:32][C@H:33]([C:41]([OH:43])=[O:42])[CH2:34][CH2:35][CH2:36][NH:37][C:38](=[NH:39])[NH2:40].[O:1]1[CH2:6][CH2:5][N:4]([C:7](=[O:27])[CH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([O:24][CH2:25][CH3:26])[C:21]([OH:23])=[O:22])=[CH:15][CH:14]=2)[C:3]2[CH:28]=[CH:29][CH:30]=[CH:31][C:2]1=2

Participants

4

Reactant 2

HCID 10180845HCID 10180845, compoundHCID 178418600HCID 178418600, compound

Product 1

HCID 178467707HCID 178467707, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-[4-{5-(3,4-Dihydro-2H-benzo[b][1,4]oxazin-4-yl)-5-oxopentylamino}phenyl]-2-ethoxypropanoic acid (120 mg, 1 eq, 0.28 mmol) obtained in example 11, and L-arginine (49 mg, 1 eq. 0.28 mmol) were taken in dry methanol (3 ml), and stirred at RT for 2-3 h. The solvent was removed on rotavapour followed by benzene azeotrope. The residue was dried under high vacuum pump to yield the title compound as a free filing solid (yield 100%), mp: 137-139° C.

Workup

  1. customThe solvent was removed on rotavapour
  2. customThe residue was dried under high vacuum pump

Sources & evidence

ORD record
ord-1e637ac87f6045f2b940ce619e6199c4
Source dataset
uspto-grants-2008_04
Patent number
US07365064B2

Reaction notes

Loading…