HCID 10201121, compound → HCID 178467709, compound

HRID 901849Notes

Reaction equation

HRID 901849 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:10]([CH2:11][CH2:12][CH2:13][NH:14][C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH:22]([O:26][CH2:27][CH3:28])[C:23]([OH:25])=[O:24])=[CH:17][CH:16]=3)[CH2:9][CH2:8][O:7][C:6]=2[CH:29]=1.[NH2:30][C@H:31]([C:39]([OH:41])=[O:40])[CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:38])[NH2:37]>CO>[NH2:30][C@H:31]([C:39]([OH:41])=[O:40])[CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:37])[NH2:38].[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:10]([CH2:11][CH2:12][CH2:13][NH:14][C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH:22]([O:26][CH2:27][CH3:28])[C:23]([OH:25])=[O:24])=[CH:17][CH:16]=3)[CH2:9][CH2:8][O:7][C:6]=2[CH:29]=1

Participants

4

Reactant 2

HCID 10201121HCID 10201121, compoundHCID 178418600HCID 178418600, compound

Product 1

HCID 178467709HCID 178467709, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-[4-{3-(7-Fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazin-4-yl)propylamino}phenyl]-2-ethoxypropanoic acid (120 mg, 1 eq, 0.298 mmol) obtained in example 17, and L-arginine (52 mg, 1 eq, 0.298 mmol) were taken in dry methanol (2 ml), and stirred at RT for 2-3 h. The solvent was removed on rotavapour followed by benzene azeotrope. The residue was dried under high vacuum pump to yield the title compound as a free flowing solid (yield 100%), mp: 158-160° C.

Workup

  1. customThe solvent was removed on rotavapour
  2. customThe residue was dried under high vacuum pump

Sources & evidence

ORD record
ord-d80eec885eec4af2b77f32235d13a7bf
Source dataset
uspto-grants-2008_04
Patent number
US07365064B2

Reaction notes

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