4-Chloroaniline → HCID 178503194, compound

HRID 901909Notes

Reaction equation

HRID 901909 reaction equation
[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1.[Cl:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1>>[Cl:11][C:12]1[CH:18]=[CH:17][C:15]([NH:16][C:7]([C:6]2[CH:9]=[CH:10][C:3]([S:2][CH3:1])=[CH:4][CH:5]=2)=[NH:8])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 78124-ChloroanilineHCID 5909604-(Methylthio)benzonitrile

Product 1

HCID 178503194HCID 178503194, compoundYield 83.26%

Procedure

The title compound was prepared from 4-methylthiobenzonitrile (11.7 g, 78 mmol) and 4-chloroaniline (10 g, 78 mmol) by following the procedure described in preparation 10 (18.06 g, yield 83.26%, purity 98.9% by HPLC). MS m/z:277.1/278.7 (M+).

Workup

  1. customdescribed in preparation 10 (18.06 g, yield 83.26%, purity 98.9% by HPLC)

Sources & evidence

ORD record
ord-e1ded83f32124277a7c0110535361d0d
Source dataset
uspto-grants-2008_04
Patent number
US07365069B2

Reaction notes

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