Pyridine-2-carbonitrile → HCID 178512043, compound

HRID 901917Notes

Reaction equation

HRID 901917 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:2].[F:9][C:10]1[CH:16]=[CH:15][C:13]([NH2:14])=[CH:12][CH:11]=1>>[F:9][C:10]1[CH:16]=[CH:15][C:13]([NH:14][C:1]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=2)=[NH:2])=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 7522Pyridine-2-carbonitrileHCID 97314-Fluoroaniline

Product 1

HCID 178512043HCID 178512043, compound

Procedure

The title compound was prepared from 2-cyanopyridine (0.94 g, 9 mmol) and 4-fluoroaniline (1 g, 9 mmol) by following the procedure described in preparation 10 (1.1 g, yield 56.81%). 1H-NMR (CDCl3):δ 6.98-7.09 (m, 2H), 7.26 (s, 2H), 7.39-7.42 (d, 1H), 7.82-7.84 (m, 1H), 8.38-8.4 (d, 1H), 8.57-8.58 (s, 1H). MS m/z: 216.3 (M+).

Sources & evidence

ORD record
ord-5e36fe17a2e84e3395ecba8f4a2c8d28
Source dataset
uspto-grants-2008_04
Patent number
US07365069B2

Reaction notes

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