4-Cyanopyridine → HCID 178466745, compound

HRID 901922Notes

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1)#[N:2].[CH2:9]([O:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1)[CH3:10]>>[CH2:9]([O:11][C:12]1[CH:18]=[CH:17][C:15]([NH:16][C:1]([C:3]2[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=2)=[NH:2])=[CH:14][CH:13]=1)[CH3:10]

Participants

Reactant 2

HCID 75064-Cyanopyridine

HCID 90764-Ethoxyaniline

Product 1

HCID 178466745HCID 178466745, compoundYield 89.3%

Procedure

The title compound was prepared from 4-cyanopyridine (7.58 g, 72 mmol) and 4-ethoxyaniline (10 g, 72 mmol) by following the procedure described in preparation 10 (15.70 g, yield 89.3%, purity 99.4% by HPLC). MS m/z:242.3 (M+).

Workup

customdescribed in preparation 10 (15.70 g, yield 89.3%, purity 99.4% by HPLC)

Sources & evidence

ORD record: ord-5955d1a88ccb4cfba335095a36df923d
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07365069B2

Reaction notes

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