HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 69313202, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Benzyl 4-(hydroxymethyl)piperidine-1-carboxylate | HCID 736490 | — |
| Reactant | (2-Bromoethoxy)-tert-butyldimethylsilane | HCID 3608067 | — |
| Product | HCID 69313202 | HCID 69313202 | 3% |
Reaction Steps
The reaction was carried out in the similar procedure to Example 75a using 5.00 g (20.1 mmol) of benzyl 4-(hydroxymethyl)piperidine-1-carboxylate, 0.88 g (20.1 mmol) of sodium hydride (55% or more, oily) and 5.28 g (22.1 mmol) of (2-bromoethoxy)-tert-butyldimethylsilane to obtain 237 mg (yield: 3%) of the title compound as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365067B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-3c7524dd4b0b410190eb17c8c1970158 |
| Source note | uspto-grants-2008_04 |