HCID 86608948, compound → HCID 85832250, compound

HRID 902055Notes

Reaction equation

HRID 902055 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH:9]1[CH2:15][NH:16][C:17](=[O:22])[C:18]([F:21])([F:20])[F:19])C1C=CC=CC=1>C(O)C.[Pd]>[CH3:14][N:11]1[CH2:12][CH2:13][NH:8][CH:9]([CH2:15][NH:16][C:17](=[O:22])[C:18]([F:21])([F:19])[F:20])[CH2:10]1

Participants

4

Reactant 1

HCID 86608948HCID 86608948, compound

Product 1

HCID 85832250HCID 85832250, compoundYield 94.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of (RS)-1-benzyl-4-methyl-2-(trifluoroacetylaminomethyl)piperazine (D3) (6.06 g, 0.0192 mol) in ethanol (300 ml) was hydrogenated at atmospheric pressure in the presence of 10% palladium on charcoal (6 g, 54% paste with water) for 18 h. The mixture was filtered through Kieselguhr and the filtrate evaporated in vacuo to furnish the title compound as a colourless gum (4.07 g, 94%).

Workup

  1. filtrationThe mixture was filtered through Kieselguhr
  2. customthe filtrate evaporated in vacuo

Sources & evidence

ORD record
ord-0249df18c1c349bb84c88e73d1a74674
Source dataset
uspto-grants-2008_04
Patent number
US07365077B2

Reaction notes

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