HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86608948, compound → HCID 85832250, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86608948 | HCID 86608948 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 85832250 | HCID 85832250 | 94.1% |
Reaction Steps
A solution of (RS)-1-benzyl-4-methyl-2-(trifluoroacetylaminomethyl)piperazine (D3) (6.06 g, 0.0192 mol) in ethanol (300 ml) was hydrogenated at atmospheric pressure in the presence of 10% palladium on charcoal (6 g, 54% paste with water) for 18 h. The mixture was filtered through Kieselguhr and the filtrate evaporated in vacuo to furnish the title compound as a colourless gum (4.07 g, 94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365077B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-0249df18c1c349bb84c88e73d1a74674 |
| Source note | uspto-grants-2008_04 |