Hydrochloric Acid → Ethyl 2-amino-4-methyl-3-oxopentanoate hydrochloride

HRID 902108Notes

Reaction equation

HRID 902108 reaction equation
[ClH:1].C(O)C.O[N:6]=[C:7]([C:13](=[O:17])[CH:14]([CH3:16])[CH3:15])[C:8]([O:10][CH2:11][CH3:12])=[O:9]>[Pd]>[ClH:1].[NH2:6][CH:7]([C:13](=[O:17])[CH:14]([CH3:16])[CH3:15])[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 178472908HCID 178472908, compound

Product 1

HCID 57434496Ethyl 2-amino-4-methyl-3-oxopentanoate hydrochloride

Reagents, catalysts & solvents 1

HCID 23938PalladiumSolvent

Procedure

10 g of HCl are introduced into 200 ml of ethanol. 46 g of ethyl 2-hydroxyimino-4-methyl-3-oxopentanoate are dissolved in this mixture, 5 g of Pd (10% on carbon) are added and the mixture is stirred under atmosphere of hydrogen (5 bar) for 8 hours. The reaction mixture is filtered through Celite and the solvent is removed under reduced pressure. This gives 45 g of ethyl 2-amino-4-methyl-3-oxopentanoate hydrochloride as a white solid.

Workup

  1. additionare added
  2. filtrationThe reaction mixture is filtered through Celite
  3. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-5ab58ea42fb2469a82780ccca82aeab0
Source dataset
uspto-grants-2008_04
Patent number
US07365084B2

Reaction notes

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