Hydrogen Peroxide → HCID 69036726, compound

HRID 902182Notes

Reaction equation

HRID 902182 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]2[O:11][N:10]=[C:9]([CH2:12][N:13]3[C:21]4[CH:20]=[CH:19][CH:18]=[C:17]([C:22]#[N:23])[C:16]=4[C:15]([CH:24]=[O:25])=[N:14]3)[CH:8]=2)=[CH:4][CH:3]=1.[OH:26]O>>[Cl:1][C:2]1[S:6][C:5]([C:7]2[O:11][N:10]=[C:9]([CH2:12][N:13]3[C:21]4[C:16](=[C:17]([C:22]#[N:23])[CH:18]=[CH:19][CH:20]=4)[C:15]([C:24]([OH:26])=[O:25])=[N:14]3)[CH:8]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 784Hydrogen PeroxideHCID 867606461-[[5-(5-Chloro-2-thienyl)-3-isoxazolyl]methyl]-3-formyl-1H-indazole-4-carbonitrile

Product 1

HCID 69036726HCID 69036726, compound

Procedure

The title compound was prepared analogously to example 1 (iii) with the difference that 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-3-formyl-1H-indazole-4-carbonitrile was used instead of 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-3-formyl-1H-indazole-5-carboxylic acid methyl ester and that a modified oxidation procedure described by E. Dalacanale et al. J. Org. Chem. (1986) 51, 567 employing H2O2 instead of 2-methylbutene was utilized.

Sources & evidence

ORD record
ord-537fc0e64c1043a3b9788ab1374e8352
Source dataset
uspto-grants-2008_04
Patent number
US07365088B2

Reaction notes

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