反应详情

To a solution of 50 mg 1H-Indazole-3-carboxylic acid in 2 mL DCM and 0.2 mL NEt3, 108 mg 1-(4-Amino-phenyl)-pyrrolidin-2-one and 79 mg BOP-Cl were added at RT and the mixture was stirred for 16 h. After the addition of 5 mL water the mixture was filtered through a chem elut® cartridge by elution with ethyl acetate and then concentrated under reduced pressure. The residue was directly subjected to the subsequent alkylation reaction without further purification.

1. filtrationwas filtered through a chem elut® cartridge by elution with ethyl acetate
2. concentrationconcentrated under reduced pressure
3. customThe residue was directly subjected to the subsequent alkylation reaction without further purification