HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-(4-Nitro-phenyl)-1H-pyridin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 178418642 | HCID 178418642 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(4-Nitro-phenyl)-1H-pyridin-4-one | HCID 19788628 | — |
Reaction Steps
A mixture of 10.1 g Pyridin-4-ol and 10 g 1-Fluoro-4-nitro-benzene and 46.1 g Cs2CO3 in 30 mL DMF was stirred at RT for 2 h. This solution was poured on to 300 mL of water and the resulting precipitate was collected by filtration to yield a bright yellow crystalline product, which was dried in vacuo. Yield: 11.2 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365088B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-b2b6195f54394a9f955b5399083889ea |
| Source note | uspto-grants-2008_04 |