Cyanamide → HCID 178457581, compound

HRID 902208Notes

Reaction equation

HRID 902208 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([NH2:11])[CH3:10].[C:12](OC)(OC)(OC)[CH2:13][CH3:14].[N:21]#[C:22][NH2:23]>>[C:22]([N:23]=[C:12]([NH:11][CH:9]([C:3]1[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=1[Cl:1])[CH3:10])[CH2:13][CH3:14])#[N:21]

Participants

4

Reactant 3

HCID 9864CyanamideHCID 1411451,1,1-TrimethoxypropaneHCID 27718581-(2,4-dichlorophenyl)ethanamine

Product 1

HCID 178457581HCID 178457581, compoundYield 84.4%

Procedure

1.85 g of 1-(2,4-dichlorophenyl)ethylamine, 1.63 g of trimethyl orthopropionate and 0.46 g of Cyanamide were heated under reflux for about 30 minutes. The volatile components were removed under reduced pressure and the residue was then titrated with water. Filtration and drying gave 2.22 g of N′-cyano-N-[1-(2,4-dichlorophenyl)ethyl]propaneimidamide of logP of 2.56.

Workup

  1. temperatureunder reflux for about 30 minutes
  2. customThe volatile components were removed under reduced pressure
  3. filtrationFiltration
  4. customdrying

Sources & evidence

ORD record
ord-4c1f3f52d390450c9858927829b700de
Source dataset
uspto-grants-2008_04
Patent number
US07365098B2

Reaction notes

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