反应详情

N-Boc-N-propyl-O-allylhydroxylamine (6.0 g) was dissolved in EtOAc (100 mL). 10% Palladium-on-carbon (0.5 g) was added, and the mixture was purged with nitrogen. The nitrogen line was exchanged for a balloon of hydrogen, and the mixture was stirred at room temperature for 6 hours. The catalyst was removed by filtration through a pad of Celite and the solvents were removed in vacuo to give a yellow oil which was purified by flash chromatography on silica gel eluting with 5% EtOAc/hexanes to give the title compound as a colorless oil (5.8 g).

1. customthe mixture was purged with nitrogen
2. customThe catalyst was removed by filtration through a pad of Celite
3. customthe solvents were removed in vacuo
4. customto give a yellow oil which
5. customwas purified by flash chromatography on silica gel eluting with 5% EtOAc/hexanes