참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Butyl bromide | HCID 8002 | — |
| 반응물 | 3-Aminobenzyl alcohol | HCID 80293 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | [3-(Butylamino)phenyl]methanol | HCID 22322603 | — |
반응 단계
To a solution of 3.69 g (30 mmol) of 3-amino benzyl alcohol in 20 ml DMSO was added 3.78 g (45 mmol) solid NaHCO3 and 2.91 ml (27 mmol) 1-bromobutane. The reaction was allowed to stir at 50° C. for 18 hours (overnight). Reaction was worked up by adding 250 ml water and product was extracted in ethyl acetate. Water was added, and the resultant mixture was extracted with EtOAc. The organic layer was washed with water and brine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07365093B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_04 |
|---|
| ORD ID | ord-ede483588b7f43ec914b02a6faa03a8e |
|---|
| 출처 메모 | uspto-grants-2008_04 |
|---|
