Gamma-Butyrolactone → N-butyl-4-hydroxybutanamide

HRID 902240Notes

Reaction equation

HRID 902240 reaction equation
[C:1]1(=[O:6])[O:5][CH2:4][CH2:3][CH2:2]1.[CH2:7]([NH2:11])[CH2:8][CH2:9][CH3:10]>>[CH2:7]([NH:11][C:1](=[O:6])[CH2:2][CH2:3][CH2:4][OH:5])[CH2:8][CH2:9][CH3:10]

Participants

3

Reactant 2

HCID 7302Gamma-ButyrolactoneHCID 8007Butylamine

Product 1

HCID 13060238N-butyl-4-hydroxybutanamide

Conditions

Temperature
85 °C

Procedure

To 30 mL (390 mmol) of g-butyrolactone was added 45 ml (455 mmol) of n-butylamine. The solution was heated at 85° C. for 1.5 hr. then the excess n-butylamine was removed in vacuo. The product crystallized on standing to give about 62 g of a colorless, low melting solid.

Workup

  1. customthen the excess n-butylamine was removed in vacuo
  2. customThe product crystallized
  3. customto give about 62 g of a colorless,

Sources & evidence

ORD record
ord-2266cc0df33048439719707d9e83214c
Source dataset
uspto-grants-2008_04
Patent number
US07365093B2

Reaction notes

Loading…