Hydrochloric Acid → HCID 11712423, compound

HRID 902249Notes

Reaction equation

HRID 902249 reaction equation
[CH2:1]([NH:8][C:9](=O)[CH:10]([C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([Cl:26])[CH:20]=1)[C:11]1([OH:18])[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:28]>>[ClH:25].[ClH:28].[CH2:1]([NH:8][CH2:9][CH:10]([C:11]1([OH:18])[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)[C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([Cl:26])[CH:20]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68855305HCID 68855305, compound

Product 1

HCID 11712423HCID 11712423, compound

Procedure

In an analogous manner to Example 1, step 2 4-[2-(benzylamino)-1-(3,4-dichlorophenyl)ethyl]-1-methylppiperidin-4-ol dihydrochloride was prepared from N-benzyl-2-(3,4-dichlorophenyl)-2-(4-hydroxy-1-methylpiperidin-4-yl)acetamide. HRMS: calcd for C21H26Cl2N2O.2.00 HCl, 464.0956; found (ESI_FT), 393.14924.

Sources & evidence

ORD record
ord-eac80a5cfa804dc19358276d4c40521f
Source dataset
uspto-grants-2008_04
Patent number
US07365076B2

Reaction notes

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