Hydrochloric Acid → HCID 68855674, compound

HRID 902261Notes

Reaction equation

[OH:1][C:2]1([CH:8]([C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([N+:35]([O-:37])=[O:36])[CH:30]=3)=[CH:25][CH:24]=2)[CH2:9][N:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[ClH:38]>>[ClH:38].[ClH:38].[N+:35]([C:31]1[CH:30]=[C:29]([C:26]2[CH:25]=[CH:24][C:23]([CH:8]([C:2]3([OH:1])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]3)[CH2:9][N:10]3[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]3)=[CH:28][CH:27]=2)[CH:34]=[CH:33][CH:32]=1)([O-:37])=[O:36]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68852318HCID 68852318, compound

Product 1

HCID 68855674HCID 68855674, compound

Procedure

In an analogous manner to Example 135, step 4, 1-[1-(3′-nitro-1,1′-biphenyl-4-yl)-2-piperazin-1-yethyl]cyclohexanol dihydrochloride was prepared from tert-butyl 4-[2-(1-hydroxycyclohexyl)-2-(3′-nitro-1,1′-biphenyl-4-yl)ethyl]piperazine-1-carboxylate. MS (ES) m/z 410.3 ([M+H]+); HRMS: calcd for C24H31N3O3.2.00 HCl, 481.1899; found (ESI), 410.2452.

Sources & evidence

ORD record: ord-e373de57d385446fbe543431fe61edef
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07365076B2

Reaction notes

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