Hydrochloric Acid → HCID 68852531, compound

HRID 902262Notes

Reaction equation

HRID 902262 reaction equation
[OH:1][C:2]1([CH:8]([C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH3:36])[CH:30]=3)=[CH:25][CH:24]=2)[CH2:9][N:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[ClH:37]>>[ClH:37].[ClH:37].[CH3:36][O:35][C:31]1[CH:30]=[C:29]([C:26]2[CH:25]=[CH:24][C:23]([CH:8]([C:2]3([OH:1])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]3)[CH2:9][N:10]3[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]3)=[CH:28][CH:27]=2)[CH:34]=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68853003HCID 68853003, compound

Product 1

HCID 68852531HCID 68852531, compound

Procedure

In an analogous manner to Example 135, step 4,1-[1-(3′-methoxy-1,1′-biphenyl-4-yl)-2-piperazin-1-ylethyl]cyclohexanol dihydrochloride was prepared from tert-butyl 4-[2-(1-hydroxycyclohexyl)-2-(3′-methoxy-1,1′-biphenyl-4-yl)ethyl]piperazine-1-carboxylate. MS (ES) m/z 395.4 ([M+H]+); HRMS: calcd for C25H34N2O2.2.00 HCl, 466.2154; found (ESI), 395.2697.

Sources & evidence

ORD record
ord-948c0f5ebd5b40c699e279c30b181fa6
Source dataset
uspto-grants-2008_04
Patent number
US07365076B2

Reaction notes

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