Decalin → HCID 69117901, compound

HRID 902322Notes

Reaction equation

HRID 902322 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:19])C=C.[CH2:20]1[CH:29]2C(CCCC2)CC[CH2:21]1>>[CH2:29]([C:10]1[CH:9]=[C:8]([F:11])[CH:7]=[C:6]([C:12]2[C:13]([Cl:19])=[CH:14][CH:15]=[CH:16][C:17]=2[Cl:18])[C:5]=1[OH:4])[CH:20]=[CH2:21]

Participants

3

Reactant 2

HCID 7044DecalinHCID 691175262-Allyloxy-2',6'-dichloro-5-fluorobiphenyl

Product 1

HCID 69117901HCID 69117901, compoundYield 84%

Procedure

A solution of 2-allyloxy-2′,6′-dichloro-5-fluorobiphenyl (11.02 g, 37 mmol) in decahydronaphthalene (100 mL) was refluxed for 38 h. The solvent was removed under vacuum. Chromatography with 0–20% ethyl acetate in hexanes afforded 9.26 g (84%) of 3-ally-2′,6′-dichloro-5-fluorobiphenyl-2-ol as a light yellow oil. MS (ES) m/z 295.0 ([M−H]−).

Workup

  1. customThe solvent was removed under vacuum

Sources & evidence

ORD record
ord-abcd63b1db3e47a1845fd4d75ce3f374
Source dataset
uspto-grants-2008_04
Patent number
US07365095B2

Reaction notes

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