Dichloromethane → 5-chloro-N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-4-(2-methylpyrazol-3-yl)furan-2-carboxamide

HRID 90234Notes

Reaction equation

HRID 90234 reaction equation
[Br:57][P+:58]([N:59]1[CH2:60][CH2:61][CH2:62][CH2:63]1)([N:64]1[CH2:65][CH2:66][CH2:67][CH2:68]1)[N:69]1[CH2:70][CH2:71][CH2:72][CH2:73]1.[CH:41]([N:42]([CH2:43][CH3:44])[CH:45]([CH3:46])[CH3:47])([CH3:48])[CH3:49].[Cl:1][c:2]1[c:3](-[c:10]2[cH:11][cH:12][n:13][n:14]2[CH3:15])[cH:4][c:5]([C:7](=[O:8])[OH:9])[o:6]1.[Cl:74][CH2:75][Cl:76].[NH2:16][CH:17]([CH2:18][N:19]1[C:20](=[O:29])[c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]2[C:27]1=[O:28])[CH2:30][c:31]1[c:32]([C:37]([F:38])([F:39])[F:40])[cH:33][cH:34][cH:35][cH:36]1.[P-:50]([F:51])([F:52])([F:53])([F:54])([F:55])[F:56]>>[Cl:1][c:2]1[c:3](-[c:10]2[cH:11][cH:12][n:13][n:14]2[CH3:15])[cH:4][c:5]([C:7](=[O:9])[NH:16][CH:17]([CH2:18][N:19]2[C:20](=[O:29])[c:21]3[cH:22][cH:23][cH:24][cH:25][c:26]3[C:27]2=[O:28])[CH2:30][c:31]2[c:32]([C:37]([F:38])([F:39])[F:40])[cH:33][cH:34][cH:35][cH:36]2)[o:6]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 2733180Bromotripyrrolidin-1-ylphosphoniumHCID 578266115-chloro-4-(1-methyl-1H-pyrazol-5-yl)-2-furancarboxylic acidHCID 1785107622-[2-amino-3-[2-(trifluoromethyl)phenyl]propyl]isoindole-1,3-dione

Product 1

HCID 765763375-chloro-N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-4-(2-methylpyrazol-3-yl)furan-2-carboxamide

Sources & evidence

ORD record
ord-8e718a47c2ad4cf1ae36e19132a21bcd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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