HCID 68964218, compound → HCID 69117516, compound

HRID 902357Notes

Reaction equation

HRID 902357 reaction equation
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:17])[C:5]=1[OH:18])[CH:2]=[CH2:3]>C(Cl)Cl.CC1C=CC=CC=1[P](C1C=CC=CC=1C)([Pd](Cl)(Cl)[P](C1=C(C)C=CC=C1)(C1C=CC=CC=1C)C1C=CC=CC=1C)C1C=CC=CC=1C>[Cl:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[C:6]1[C:5]([OH:18])=[C:4]([CH:1]=[CH:2][CH3:3])[CH:9]=[CH:8][C:7]=1[Cl:10]

Participants

4

Reactant 1

HCID 68964218HCID 68964218, compound

Product 1

HCID 69117516HCID 69117516, compoundYield 48.4%

Reagents, catalysts & solvents 2

HCID 178424406HCID 178424406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

Treatment of 3-allyl-2′,6-dichloro-biphenyl-2-ol (6.2 g, 22.2 mmol) in methylene chloride (200 mL) with dichlorobis(acetonitrile)palladium (II) (0.86 g, 3.3 mmol) according to the procedure described for Example 69, Step 5 provided 3.0 g (48%) of 2′,6-dichloro-3-(prop-1-enyl)biphenyl-2-ol as a light yellow oil.

Sources & evidence

ORD record
ord-eb55b092b8fc41a3a96a6a0283a925b6
Source dataset
uspto-grants-2008_04
Patent number
US07365095B2

Reaction notes

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