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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 902363Generated: October 27, 2026

2'-Chloro-2-fluoro-6-methoxybiphenyl → 2'-Chloro-6-fluorobiphenyl-2-ol

https://huagongshe.com/reaction/902363

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2'-Chloro-2-fluoro-6-methoxybiphenylHCID 68961415—
SolventHydrogen BromideHCID 260—
Product2'-Chloro-6-fluorobiphenyl-2-olHCID 6911751757%

Reaction Steps

Treatment of 2′-chloro-2-fluoro-6-methoxybiphenyl (17.0 g) with hydrogen bromide (33% in acetic acid, 60 mL) according to the procedure described for Example 69, Step 2 provided 7.5 g (57%) of 2′-chloro-6-fluorobiphenyl-2-ol as a colorless oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07365095B2
Source datasetuspto-grants-2008_04
ORD IDord-9d28d4db4b574c46851ace7569cb593d
Source noteuspto-grants-2008_04