Mesitylene → HCID 69117595, compound

HRID 902364Notes

Reaction equation

HRID 902364 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:18])C=C.[C:19]1(C)[CH:24]=C(C)C=C(C)[CH:20]=1>>[CH2:24]([C:10]1[CH:9]=[CH:8][C:7]([F:11])=[C:6]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])[C:5]=1[OH:4])[CH:19]=[CH2:20]

Participants

3

Reactant 2

HCID 7947MesityleneHCID 69117933HCID 69117933, compound

Product 1

HCID 69117595HCID 69117595, compoundYield 81%

Procedure

A solution of 2-allyloxy-2′-chloro-6-fluorobiphenyl (9.0 g, 33.7 mmol) in mesitylene (100 mL) was refluxed for 24 h. The solvent was removed under reduced pressure. Purification by ISCO using a solvent gradient of 0 to 20% ethyl acetate in hexanes provided 7.0 g (81%) of 3-allyl-2′-chloro-6-fluorobiphenyl-2-ol as a colorless oil.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customPurification by ISCO

Sources & evidence

ORD record
ord-82ab16d00c21490d85020ee616ff8340
Source dataset
uspto-grants-2008_04
Patent number
US07365095B2

Reaction notes

Loading…