HCID 69117595, compound → HCID 69116903, compound

HRID 902365Notes

Reaction equation

HRID 902365 reaction equation
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:17])[C:5]=1[OH:18])[CH:2]=[CH2:3]>C(Cl)Cl.CC1C=CC=CC=1[P](C1C=CC=CC=1C)([Pd](Cl)(Cl)[P](C1=C(C)C=CC=C1)(C1C=CC=CC=1C)C1C=CC=CC=1C)C1C=CC=CC=1C>[Cl:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[C:6]1[C:5]([OH:18])=[C:4]([CH:1]=[CH:2][CH3:3])[CH:9]=[CH:8][C:7]=1[F:10]

Participants

4

Reactant 1

HCID 69117595HCID 69117595, compound

Product 1

HCID 69116903HCID 69116903, compoundYield 39.4%

Reagents, catalysts & solvents 2

HCID 178424406HCID 178424406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

Treatment of 3-allyl-2′-chloro-6-fluoro-biphenyl-2-ol (3.8 g, 14.5 mmol) in methylene chloride (150 mL) with dichlorobis(acetonitrile)palladium (II) (0.56 g, 2.2 mmol) according to the procedure described for Example 69, Step 5 provided 1.5 g (39%) of 2′-chloro-6-fluoro-3-(prop-1-enyl)biphenyl-2-ol as a light yellow oil.

Sources & evidence

ORD record
ord-dabe08510cf24ab3ac2faa7c79fab566
Source dataset
uspto-grants-2008_04
Patent number
US07365095B2

Reaction notes

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