HCID 69116784, compound → HCID 58629987, compound

HRID 902371Notes

Reaction equation

HRID 902371 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14]C)=[CH:12][CH:11]=[CH:10][C:9]=2[F:16])=[C:4]([CH3:17])[CH:3]=1>Br>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([OH:14])=[CH:12][CH:11]=[CH:10][C:9]=2[F:16])=[C:4]([CH3:17])[CH:3]=1

Participants

3

Reactant 1

HCID 69116784HCID 69116784, compound

Product 1

HCID 58629987HCID 58629987, compoundYield 86.1%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

Treatment of 4-chloro-2′-fluoro-6′-methoxy-2-methylbiphenyl (2.7 g, 10.8 mmol) with hydrogen bromide (33% in acetic acid, 50 mL) according to the procedure described for Example 69, Step 2 provided 2.2 g (86%) of 4′-chloro-6-fluoro-2′-methylbiphenyl-2-ol as a colorless oil.

Sources & evidence

ORD record
ord-28d0f769045444dd8ff0dfd83806b619
Source dataset
uspto-grants-2008_04
Patent number
US07365095B2

Reaction notes

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