HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 69117472, compound → 4'-Chloro-6-fluoro-2'-methyl-3-(prop-1-enyl)biphenyl-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 69117472 | HCID 69117472 | — |
| Catalyst | HCID 178424406 | HCID 178424406 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4'-Chloro-6-fluoro-2'-methyl-3-(prop-1-enyl)biphenyl-2-ol | HCID 69117422 | 80.1% |
Reaction Steps
Treatment of 3-allyl-4′-chloro-6-fluoro-2′-methylbiphenyl-2-ol (2.0 g, 7.22 mmol) in methylene chloride (70 mL) with dichlorobis(acetonitrile)palladium (II) (0.25 g, 1.0 mmol) according to the procedure described for Example 69, Step 5 provided 1.6 g (80%) of 4′-chloro-6-fluoro-2′-methyl-3-(prop-1-enyl)biphenyl-2-ol as a colorless oil, MS (ESI) m/z 275.00 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365095B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-80b1a53123cf4fd3b47e96da289ffbac |
| Source note | uspto-grants-2008_04 |