HuagongsheHuagongshe Chemistry Print Report · For research reference only
Allyl bromide → 2'-Allyloxy-2,4-dichloro-6'-fluorobiphenyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Allyl bromide | HCID 7841 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2',4'-Dichloro-6-fluoro-biphenyl-2-ol | HCID 69118158 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2'-Allyloxy-2,4-dichloro-6'-fluorobiphenyl | HCID 69117199 | 92.3% |
Reaction Steps
Treatment of 2′,4′-dichloro-6-fluorobiphenyl-2-ol (1.6 g, 6.2 mmol) with potassium carbonate (1.3 g, 9.3 mmol) and allyl bromide (0.79 mL, 9.3 mmol) in DMSO (50 mL) according to the procedure described for Example 69, Step 3 provided 1.7 g (92%) of 2′-allyloxy-2,4-dichloro-6′-fluorobiphenyl as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365095B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-54f17654ded54c1cbfed12a2fda8190e |
| Source note | uspto-grants-2008_04 |