HCID 69117214, compound → HCID 69117466, compound

HRID 902383Notes

Reaction equation

HRID 902383 reaction equation
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[C:6]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[Cl:18])[C:5]=1[OH:19])[CH:2]=[CH2:3]>C(Cl)Cl.CC1C=CC=CC=1[P](C1C=CC=CC=1C)([Pd](Cl)(Cl)[P](C1=C(C)C=CC=C1)(C1C=CC=CC=1C)C1C=CC=CC=1C)C1C=CC=CC=1C>[Cl:18][C:12]1[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]=1[C:6]1[C:5]([OH:19])=[C:4]([CH:1]=[CH:2][CH3:3])[CH:9]=[CH:8][C:7]=1[F:10]

Participants

4

Reactant 1

HCID 69117214HCID 69117214, compound

Product 1

HCID 69117466HCID 69117466, compoundYield 73%

Reagents, catalysts & solvents 2

HCID 178424406HCID 178424406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

Treatment of 3-allyl-2′,4′-dichloro-6-fluorobiphenyl-2-ol (1.1 g, 3.70 mmol) with dichlorobis(acetonitrile)palladium (II) (0.15 g, 0.58 mmol) in methylene chloride (50 mL) according to the procedure described for Example 69, Step 5 provided 0.8 g (73%) of 2′,4′-dichloro-6-fluoro-3-(prop-1-enyl)biphenyl-2-ol as a pale yellow oil.

Sources & evidence

ORD record
ord-a45c05b199424df8ab38a57f91a41cba
Source dataset
uspto-grants-2008_04
Patent number
US07365095B2

Reaction notes

Loading…