Mesitylene → HCID 69117241, compound

HRID 902391Notes

Reaction equation

HRID 902391 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)C=C.[C:24]1(C)[CH:29]=C(C)C=C(C)[CH:25]=1>>[CH2:29]([C:10]1[CH:9]=[C:8]([F:11])[CH:7]=[C:6]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:5]=1[OH:4])[CH:24]=[CH2:25]

Participants

3

Reactant 2

HCID 7947MesityleneHCID 69118446HCID 69118446, compound

Product 1

HCID 69117241HCID 69117241, compoundYield 96%

Procedure

A solution of 2-allyloxy-5-fluoro-2′-phenylbiphenyl (6.4 g, 21.0 mmol) in mesitylene (200 mL) was refluxed for 72 h. The solvent was removed under reduced pressure. Purification by ISCO using a solvent gradient of 0 to 20% ethyl acetate in hexanes afforded 6.2 g (96%) of 3-allyl-5-fluoro-2′-phenylbiphenyl-2-ol as a pale yellow oil.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customPurification by ISCO

Sources & evidence

ORD record
ord-1090f1077eb748e08a9f85e10fae2b88
Source dataset
uspto-grants-2008_04
Patent number
US07365095B2

Reaction notes

Loading…