HCID 69117241, compound → HCID 69117474, compound

HRID 902392Notes

Reaction equation

HRID 902392 reaction equation
[CH2:1]([C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:5]=1[OH:23])[CH:2]=[CH2:3]>C(Cl)Cl.CC1C=CC=CC=1[P](C1C=CC=CC=1C)([Pd](Cl)(Cl)[P](C1=C(C)C=CC=C1)(C1C=CC=CC=1C)C1C=CC=CC=1C)C1C=CC=CC=1C>[F:10][C:8]1[CH:7]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:5]([OH:23])=[C:4]([CH:1]=[CH:2][CH3:3])[CH:9]=1

Participants

4

Reactant 1

HCID 69117241HCID 69117241, compound

Product 1

HCID 69117474HCID 69117474, compoundYield 93.2%

Reagents, catalysts & solvents 2

HCID 178424406HCID 178424406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

Treatment of 3-allyl-5-fluoro-2′-phenylbiphenyl-2-ol (3.0 g, 9.8 mmol) in methylene chloride (100 mL) with dichlorobis(acetonitrile)palladium (II) (0.50 g, 1.93 mmol) according to the procedure described for Example 69, Step 5 provided 2.78 g (93%) of 5-fluoro-2′-phenyl-3-(prop-1-enyl)biphenyl-2-ol as a pale yellow oil.

Sources & evidence

ORD record
ord-6346184714f444c09e85fb1cebc1ed77
Source dataset
uspto-grants-2008_04
Patent number
US07365095B2

Reaction notes

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