反应详情

Treatment of (2R)-2-(5-fluoro-2′-phenyl-3-(prop-1-enyl)biphenyl-2-yloxy)but-3-enyl 4-methylbenzenesulfonate (1.8 g, 3.40 mmol) with benzylidene-bis(tricyclohexylphosphine)-dichlororuthenium (1.0 g, 1.22 mmol) in 1,2-dichloroethane (100 mL) according to the procedure described for Example 69, Step 7 provided 1.36 g (82%) of ((2R)-8-(biphenyl-2-yl)-6-fluoro-2H-chromen-2-yl)methyl 4-methylbenzenesulfonate as a brown solid. MS (ESI) m/z 504.1 ([M+NH4]+).