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HRID902444

反应详情

EQUATION

反应方程式

HRID 902444 的结构方程式

REACTANTS

反应物

2
结构：ClCl
HCID24526

Chlorine

Cl2

结构：CCOc1cc2[nH]cc(C#N)c(=O)c2cc1NC(C)=O
HCID11459935

N-(3-Cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide

C14H13N3O3

PRODUCTS

生成物

1
结构：CCOc1cc2ncc(C#N)c(Cl)c2cc1NC(C)=O
HCID11358234

N-(4-Chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide

C14H12ClN3O2

PROCEDURE

实验过程

3-Cyano-7-ethoxy-4-hydroxy-6-N-acetylquinoline 6 was reacted with a chlorine-substituting reagent to yield 4-Chloro-3-cyano-7-ethoxy-6-N-acetylquinoline 7 followed by condensation with 3-chloro-4-fluoroaniline optionally in the presence of acid to yield N-[4-(3-Chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-acetamide 8.