HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide | HCID 11459935 | — |
| Product | N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide | HCID 11358234 | — |
Reaction Steps
3-Cyano-7-ethoxy-4-hydroxy-6-N-acetylquinoline 6 was reacted with a chlorine-substituting reagent to yield 4-Chloro-3-cyano-7-ethoxy-6-N-acetylquinoline 7 followed by condensation with 3-chloro-4-fluoroaniline optionally in the presence of acid to yield N-[4-(3-Chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-acetamide 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365203B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-d3dc4ff8e5884eff9e861b5c7b68fd72 |
| Source note | uspto-grants-2008_04 |