Hydrochloric Acid → 7-(2,4-dichloro-phenyl)-2-methyl-2H-pyrazolo[3,4-c]pyridine hydrochloride

HRID 902544Notes

Reaction equation

HRID 902544 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]2=[N:15][N:16]([CH3:18])[CH:17]=[C:13]2[CH:12]=[CH:11][N:10]=1.Cl>C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]2=[N:15][N:16]([CH3:18])[CH:17]=[C:13]2[CH:12]=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 597023037-(2,4-dichloro-phenyl)-2-methyl-2H-pyrazolo[3,4-c]pyridine

Product 1

HCID 686142437-(2,4-dichloro-phenyl)-2-methyl-2H-pyrazolo[3,4-c]pyridine hydrochlorideYield 197.1%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of 7-(2,4-dichloro-phenyl)-2-methyl-2H-pyrazolo[3,4-c]pyridine (0.029 g, 0.10 mmol) in 1 mL of diethyl ether was added 0.100 mL of a 2 M solution of HCl in ether. The resulting white suspension was stirred for 15 m then concentrated to afford 0.031 g of 7-(2,4-dichloro-phenyl)-2-methyl-2H-pyrazolo[3,4-c]pyridine hydrochloride (32 HCl) as an off-white solid: m.p. 191-196.

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-a19230c7808844869dc91efc803a79ae
Source dataset
uspto-grants-2008_04
Patent number
US07365211B2

Reaction notes

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