Water → HCID 23122213, compound

HRID 902566Notes

Reaction equation

HRID 902566 reaction equation
C(=O)([O-])[O-].[K+].[K+].Cl[C:8]([O:10][CH2:11][CH3:12])=[O:9].O.[NH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19]>CC(C)=O.O>[CH2:11]([O:10][C:8]([NH:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19])=[O:9])[CH3:12]

Participants

6

Reactant 4

HCID 962WaterHCID 10928Ethyl chloroformateHCID 11430Potassium CarbonateHCID 258684-Amino-1-butanol

Product 1

HCID 23122213HCID 23122213, compound

Reagents, catalysts & solvents 1

HCID 18366337Propan-2-one--water (1/1)Solvent

Procedure

In an amount of 25.5 g of 4-aminobutanol was dissolved in 255 ml of a mixed solvent of acetone/water (3:1). Under ice cooling, the mixture was added with 43.5 g of potassium carbonate, added dropwise with 27.6 ml of ethyl chloroformate over 13 minutes, and then stirred for 2 hours. The reaction mixture was added with 100 ml of water, and extracted with 100 ml of ethyl acetate, and then the organic layer was washed with saturated brine. The organic layer was dried over anhydrous magnesium sulfate, and then filtered. The filtrate was concentrated under reduced pressure to obtain 45.3 g of 4-ethoxycarbonylaminobutanol. Physicochemical Properties of this Compound

Workup

  1. extractionextracted with 100 ml of ethyl acetate
  2. washthe organic layer was washed with saturated brine
  3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d30f4d831c86481082ce9a537e5f8f8e
Source dataset
uspto-grants-2008_04
Patent number
US07365174B2

Reaction notes

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