Hydrochloric Acid → HCID 13096512, compound

HRID 902610Notes

Reaction equation

HRID 902610 reaction equation
[CH:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([OH:10])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[CH3:18]O>>[CH3:18][O:9][C:8](=[O:10])[CH:7]([CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 97942alpha-Cyclohexylphenylacetic acid

Product 1

HCID 13096512HCID 13096512, compoundYield 99%

Procedure

To a stirring solution of 2-cyclohexyl-2-phenyl-acetic acid (2 g, 0.0091 mole) in methanol (100 mL) was added HCl (2 mL), and the mixture was heated at reflux for 5 hours. Methanol was removed, the residue was dissolved in ethyl acetate, and washed with saturated NaHCO3. The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo to give 2.2 g (99% yield) of the title compound as an oil. MS (ESI) 233.2 (M+H+).

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 5 hours
  3. customMethanol was removed
  4. dissolutionthe residue was dissolved in ethyl acetate
  5. washwashed with saturated NaHCO3
  6. dry with materialThe organic layer was dried over sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6947704bfca7408b93b8133fc68891f3
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

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