反应详情

A mixture of 4-pyridylacetic acid hydrochloride (5 g, 28.8 mmol), glacial acetic acid (100 mL) and PtO2 (0.5 g) was hydrogenated at 50 psi overnight. The solvent was decanted from the catalyst and concentrated in vacuo. Azetroped with toluene twice then washed with ether to give 5 g (97%) of white solid. MS(ESI) 144.0 (M+H+).

1. customwas hydrogenated at 50 psi overnight
2. customThe solvent was decanted from the catalyst
3. concentrationconcentrated in vacuo
4. washAzetroped with toluene twice then washed with ether