HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → [4-(3-Hydroxy-phenyl)-piperidin-1-yl]-acetic Acid Hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | [4-(3-Methoxy-phenyl)-piperidin-1-yl]-acetic Acid Methyl Ester | HCID 69252936 | — |
| Product | [4-(3-Hydroxy-phenyl)-piperidin-1-yl]-acetic Acid Hydrobromide | HCID 69253902 | — |
Reaction Steps
A mixture of [4-(3-methoxy-phenyl)-piperidin-1-yl]-acetic acid methyl ester and HBr (48%, 2 mL) was refluxed for 1 h. The reaction mixture was concentrated in vacuo, azeotroped with toluene twice and washed with ether to give white solid (1.2 g, quantitative yield). MS(ESI) 236.0 (M+H+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365085B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-47faee2d991441c695d29cbb25066afd |
| Source note | uspto-grants-2008_04 |