反应详情

A mixture of [4-(3-methoxy-phenyl)-piperidin-1-yl]-acetic acid methyl ester and HBr (48%, 2 mL) was refluxed for 1 h. The reaction mixture was concentrated in vacuo, azeotroped with toluene twice and washed with ether to give white solid (1.2 g, quantitative yield). MS(ESI) 236.0 (M+H+)

1. temperaturewas refluxed for 1 h
2. concentrationThe reaction mixture was concentrated in vacuo
3. customazeotroped with toluene twice
4. washwashed with ether