2-Chloro-3-(trifluoromethyl)benzaldehyde → HCID 86760660, compound

HRID 902646Notes

Reaction equation

HRID 902646 reaction equation
[Cl:1][C:2]1[C:21]([C:22]([F:25])([F:24])[F:23])=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][NH:5][CH:6](F)[CH2:7][C:8](F)(F)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11]C=1.[N:26]1(C(C2C=CC=CC=2)CN)[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1.ClC1C(C(F)(F)F)=CC=CC=1C=O.FCC(CF)(CF)C(C1C=CC=CC=1)=O>>[Cl:1][C:2]1[C:21]([C:22]([F:23])([F:24])[F:25])=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][NH:5][CH2:6][CH:7]([N:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1)[C:8]1[CH:9]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

5

Reactant 4

HCID 27366722-Chloro-3-(trifluoromethyl)benzaldehydeHCID 31585832-Morpholin-4-yl-2-phenylethylamineHCID 66939902HCID 66939902, compoundHCID 86760661HCID 86760661, compound

Product 1

HCID 86760660HCID 86760660, compound

Procedure

Following the procedure (preparation of rac-±-(2-chloro-3-trifluoromethyl-benzyl)-(trifluoro-phenyl-propyl)-amine) of Example 64, step (a) except rac-±-2-Morpholin4-yl-2-phenyl-ethylamine was used in step (a) instead of 2-chloro-3-(α,α,α-trifluoromethyl)benzylamine, and 2-chloro-3-trifluoromethyl benzaldehyde was used instead of (α,α,α-trifluoromethylphenylacetaldehyde, the title compound was sythesized as an oil, 0.27 g (88%); MS (ESI) 399 (M+H+).

Sources & evidence

ORD record
ord-4d31f85e8a0f46eab7e672e78c92aef0
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

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